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PSRICalc - Plant Stress Response Index Calculator

Calculate Plant Stress Response Index (PSRI) from time-series germination data with optional radicle vigor integration. Built on the methodological foundation of the Osmotic Stress Response Index (OSRI) framework developed by Walne et al. (2020) <doi:10.1002/agg2.20087>. Provides clean, direct PSRI calculations suitable for agricultural research and statistical analysis. Note: This package implements methodology currently under peer review. Please contact the author before publication using this approach.

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2.70 score 1 stars 173 downloads

GALAHAD - Geometry-Adaptive Lyapunov-Assured Hybrid Optimizer with Softplus Reparameterization and Trust-Region Control

Implements the GALAHAD algorithm (Geometry-Adaptive Lyapunov-Assured Hybrid Optimizer), updated in version 2 to replace the hard-clamp positivity constraint of v1 with a numerically smooth softplus reparameterization, add rho-based trust-region adaptation (actual vs. predicted objective reduction), extend convergence detection to include both absolute and relative function-stall criteria, and enrich the per-iteration history with Armijo backtrack counts and trust-region quality ratios. Parameters constrained to be positive (rates, concentrations, scale parameters) are handled in a transformed z-space via the softplus map so that gradients remain well-defined at the constraint boundary. A two-partition API (positive / euclidean) replaces the three-way T/P/E partition of v1; the legacy form is still accepted for backwards compatibility. Designed for biological modeling problems (germination, dose-response, prion RT-QuIC, survival) where rates, concentrations, and unconstrained coefficients coexist. Developed at the Minnesota Center for Prion Research and Outreach (MNPRO), University of Minnesota. Based on Conn et al. (2000) <doi:10.1137/1.9780898719857>, Barzilai and Borwein (1988) <doi:10.1093/imanum/8.1.141>, Xu and An (2024) <doi:10.48550/arXiv.2409.14383>, Polyak (1969) <doi:10.1016/0041-5553(69)90035-4>, Nocedal and Wright (2006, ISBN:978-0-387-30303-1), and Dugas et al. (2009) <https://www.jmlr.org/papers/v10/dugas09a.html>.

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2.00 score 442 downloads

KWELA - Hierarchical Adaptive 'RT-QuIC' Classification for Complex Matrices

Extends 'RT-QuIC' (Real-Time Quaking-Induced Conversion) statistical analysis to complex environmental matrices through hierarchical adaptive classification. 'KWELA' is named after a deity of the Fore people of Papua New Guinea, among whom Kuru, a notable human prion disease, was identified. Implements a 6-layer architecture: hard gate biological constraints, per-well adaptive scoring, separation-aware combination, Youden-optimized cutoffs, replicate consensus, and matrix instability detection. Features dual-mode operation (diagnostic/research), auto-profile selection (Standard/Sensitive/Matrix-Robust), RAF integration for artifact detection, matrix-aware baseline correction, and multiple consensus rules. Methods include energy distance (Szekely and Rizzo (2013) <doi:10.1016/j.jspi.2013.03.018>), CRPS (Gneiting and Raftery (2007) <doi:10.1198/016214506000001437>), SSMD (Zhang (2007) <doi:10.1016/j.ygeno.2007.01.005>), and Jensen-Shannon divergence (Lin (1991) <doi:10.1109/18.61115>). This package implements methodology currently under peer review; please contact the author before publication using this approach. Development followed an iterative human-machine collaboration where all algorithmic design, statistical methodologies, and biological validation logic were conceptualized, tested, and iteratively refined by Richard A. Feiss through repeated cycles of running experimental data, evaluating analytical outputs, and selecting among candidate algorithms and approaches. AI systems ('Anthropic Claude' and 'OpenAI GPT') served as coding assistants and analytical sounding boards under continuous human direction. The selection of statistical methods, evaluation of biological plausibility, and all final methodology decisions were made by the human author. AI systems did not independently originate algorithms, statistical approaches, or scientific methodologies.

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1.70 score 146 downloads

PSRICalcSM - Plant Stress Response Index Calculator - Softmax Method

Implements the softmax aggregation method for calculating Plant Stress Response Index (PSRI) from time-series germination data under environmental stressors including prions, xenobiotics, osmotic stress, heavy metals, and chemical contaminants. Provides zero-robust PSRI computation through adaptive softmax weighting of germination components (Maximum Stress-adjusted Germination, Maximum Rate of Germination, complementary Mean Time to Germination, and Radicle Vigor Score), eliminating the zero-collapse failure mode of the geometric mean approach implemented in 'PSRICalc'. Includes perplexity-based temperature parameter calibration and modular component functions for transparent germination analysis. Built on the methodological foundation of the Osmotic Stress Response Index (OSRI) framework developed by Walne et al. (2020) <doi:10.1002/agg2.20087>. Note: This package implements methodology currently under peer review. Please contact the author before publication using this approach. Development followed an iterative human-machine collaboration where all algorithmic design, statistical methodologies, and biological validation logic were conceptualized, tested, and iteratively refined by Richard A. Feiss through repeated cycles of running experimental data, evaluating analytical outputs, and selecting among candidate algorithms and approaches. AI systems (Anthropic Claude and OpenAI GPT) served as coding assistants and analytical sounding boards under continuous human direction. The selection of statistical methods, evaluation of biological plausibility, and all final methodology decisions were made by the human author. AI systems did not independently originate algorithms, statistical approaches, or scientific methodologies.

Last updated

1.70 score 146 downloads